Spirapro PharmaPilot from Koch Membrane Systems is a compact crossflow MF, UF, NF and RO filtration system that allows the development and scale-up of the major relevant process parameters for large-scale production in line with current good manufacturing practice (cGMP) guidelines. It covers the whole range of pharmaceutical and biotechnological crossflow applications such as clarification, concentration, fractionation, desalting and purification, while providing suspended solids removal, protein concentration, removal of macro molecules and proteins. Additional applications include desalting of product streams and concentration of small molecules in aqueous solutions to reduce volume for lypholisation (freeze drying). The pilot system accommodates 2540 style spiral wound membrane elements and has the ability to operate one or two housings in series or parallel. It features a 25 l process vessel with the option to upgrade to 100 l or connection to an external process vessel. Operating pressure is up to 40 bar with a speed controlled feed/recirculation pump to allow pressure and flow variation.
Hall 4.0, Booth L1
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