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Production of HPW/WFI

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Production of HPW/WFI

Production of HPW/WFI
With Osmotron Inject the ultrapure water specialist Christ introduces a plant for the production of HPW by means of two reverse osmosis stages and electro-deionisation. The compact unit is entirely hot water-sanitisable and constitutes a safe, closed system. For applications calling for an integrity test, a plant configuration replacing the second reverse osmosis stage with an ultrafiltration stage is preferably used.

In both configurations, after having passed the security filter, softened water reaches the reverse osmosis at a high pressure as the first process step. The major part of the water passes through the membrane with a residual salt content of approximately two per cent, leaving most of the dissolved and any suspended matter behind. In the next step, the permeate passes to the patented, temperature-stable Christ electro-deionisation module Septrosan, where it is fully demineralised. This treatment also reduces pyrogens and microbial contamination to a great extent due to the very high pH gradients of pH 2 to pH 12. The last process step is reverse osmosis or ultrafiltration. When an integrity test is required a UF stage is used. The hollow fibre UF module is also sanitisable and can be completely drained. The cut-off rating used (MWCO) is 6,000 Dalton. The double skinned asymmetrical membranes and the deadspace-free, entirely resin potted, construction offers the highest security. To integrity test the UF modules the concentrate (reject water) chambers are emptied and pressurised air is applied. A deficient module is identified when air bubbles are observed moving upwards on the filtrate side.
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