Focus on solids and liquids at Achema

Two sides to the pharmaceutical world

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The Bosch Packaging Technology exhibit at Achema will show two sides of the pharmaceutical world: divided into Pharma Liquid and Pharma Solid, it will highlight market novelties and portfolio expansions along with digital solutions and services, which together add up to optimally harmonised systems for all production processes.

At Achema 2018, Bosch Packaging Technology will focus on its R&D, line and service competencies, complemented by comprehensive Industry 4.0 solutions. Visitors to the Liquid World can witness a market debut: a preparation system combined with a filling machine for sterile injection solutions. The synchronised components enable an efficient design phase. This integrated solution can then be realised and qualified quickly and easily thanks to Bosch’s line competence. The new SVP250 LF process system for manufacturing injection solutions was developed by Pharmatec, the Bosch subsidiary. The conical shape of the process containers allows a broad production range from 15 to 250 l with only minimal product loss. For the product transfer from the preparation system to the ALF 5000 filling and closing machine, Bosch will showcase preconfigured versions for different product characteristics, such as clear solutions or suspensions. The process and filling systems communicate with each other by exchanging data via the control panels, thus creating a connected system – an advantage for future Industry 4.0 applications.

Focus on safety and flexibility

Bosch will additionally demonstrate safe biopharmaceutical processing with a customised MHD system for aseptic filling. High quality is guaranteed by 100 % in-process controls and the system offers maximum flexibility regarding packaging types, such as pre-sterilised vials and syringes, owing to the use of robotic technology in the isolator. It is also equipped for other types of packaging as well as alternating processes.

Amongst other inspection technologies, the AIM 3 allows safe testing of glass containers. With its small footprint, the machine combines cosmetic and particle inspection as well as high-voltage leak detection of even the tiniest cracks in the glass. Defective containers are separated during a pre-inspection to prevent glass breakage in the main inspection process. The automatic re-inspection makes sure that only defective products and containers are removed, thus reducing the false reject rate.

From continuous to containment

Bosch has expanded its portfolio for continuous manufacturing with the Xelum R&D. This entry-level unit will be unveiled to selected customers at Achema 2018. It is based on the Xelum platform, which was especially developed for continuous production by Hüttlin, another Bosch subsidiary. The Xelum R&D stands for short development times with low API consumption. It offers customers the shortest way from development to continuous manufacturing – with no time-consuming scale-up. Hüttlin will also underline its pioneering role in batch technology: Solidlab 1 and 2, as well as the HDGC fluid bed system, enable fast process times with little product loss.

The GKF 720 is another market novelty. Thanks to its washable containment, this flexible platform for small batches sets new standards when it comes to safe processing of highly potent solid dosage forms. Users benefit from fast product changes and short cleaning times with reduced water consumption.

The pharmaceutical portfolio is rounded off by complementary secondary packaging solutions. As one typical example, Bosch will show the CPS 1900 WTE module with tamper-evident function and integrated checkweigher for reliable serialisation of folding cartons. The new reworks station allows easier handling of all serialisation and aggregation data – even after production has finished.

Industry 4.0 solutions

Apart from safety along the supply chain, Bosch’s Industry 4.0 solutions also ensure transparency in production. Real-time information provides customers with all the necessary data for monitoring the machine status or process parameters. In addition to data services, the Bosch exhibit will include the Pharma MES:SE browser-based software solution for GMP environments. The starter edition captures, stores and visualises machine data. As with all other Industry 4.0 solutions, Bosch combines proprietary software and processing expertise to give customers a solution which is exactly tailored to the requirements of the pharmaceutical industry. Operators profit from quick reaction times in case of deviations. Pharma MES:SE also helps to analyse and improve overall equipment effectiveness (OEE).

By capturing machine data, services such as predictive, preventive or remote maintenance can be used more efficiently. Bosch’s global presence with local service technicians and training centres, as well as the online ordering platform E-Portal, mean customers can take advantage of comprehensive, worldwide after-sales services.

Bosch Packaging Technology

Halle 3.1, Stand C71

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