Small-scale crossflow filter module
The single-use ultrafilter Sartocon Slice 50 from Sartorius Stedim Biotech is designed for use in biotechnological applications. The filter device is offered as an encapsulated and ready-to-use crossflow module with a filter area of 50 cm2 and a wide variety of molecular weight cutoffs. The cGMP validated self-contained unit eliminates the need for a compression holder and is available in a choice of two polymers: The Hydrosart membrane is a stable polymer suitable for a broad pH range and can be depyrogenated using NaOH at elevated temperatures. It is extremely hydrophilic, making it non-protein-binding and virtually non-fouling, and delivers an exceptional high flux. The polyethersulfone membrane (PESU), which is well established in the biotechnological and pharmaceutical industries, is a stable polymer that is ideal for a broad pH and temperature range. A major benefit of the crossflow filter device is its linear scalability, along with identical materials of construction. This eases the transfer of process development results to the next scale up level.
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